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                <h1 class="display-3">追曙光 穿星海</h1>
                <p class="lead">真实世界的联合BF839混合益生菌制剂<br>对儿童孤独症谱系障碍干预的临床效果评价研究</p>
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        <section class="clinical-section" id="clinical-evidence">
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                <h2 class="text-center mb-4">研究已证实二代菌及肠菌移植均能显著改善ASD核心症状</h2>
                <div class="row">
                    <div class="col-md-6">
                        <h4>二代菌(NGPs)干预孤独症的临床成果</h4>
                        <p>中国研究者2024年发表的双盲试验表明，<a href="https://totemlife.cn/totembio/cui-ruo-ni-gang-jun-bf839-2/">二代菌中的脆弱拟杆菌</a>BF839能显著改善孤独症儿童的社交与认知能力，并改善多种共患病</p>
                        <!--img src="art-image.jpg" class="img-fluid" alt="BF839临床效果图"-->
                        <!-- 替换为文字表格 -->
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                        <table class="table table-bordered table-hover">
                            <thead class="table-custom">
                                <tr>
                                    <th>评估指标</th>
                                    <th>安慰剂组改善</th>
                                    <th>BF839组改善</th>
                                    <th>P值（显著性）</th>
                                </tr>
                            </thead>
                            <tbody>
                                <tr>
                                    <td>[1]ABC总分</td>
                                    <td>-5.05 ± 16.58</td>
                                    <td>-19.71 ± 24.12</td>
                                    <td>0.047</td>
                                </tr>
                                <tr>
                                    <td>[2]ABC行为</td>
                                    <td>-0.32 ± 5.88</td>
                                    <td>-5.71 ± 8.26</td>
                                    <td>0.034</td>
                                </tr>
                                <tr>
                                    <td>[3]CARS评分</td>
                                    <td>-2.11 ± 3.70</td>
                                    <td>-5.57 ± 5.79</td>
                                    <td>0.044</td>
                                </tr>
                                <tr>
                                    <td>[4]GSRS评分</td>
                                    <td>2.00 (-3.00, 3.00)</td>
                                    <td>-3.50 (-7.13, -1.25)</td>
                                    <td>0.014</td>
                                </tr>
                            </tbody>
                        </table>
                        </div>
                        <small>
                            [1] 原文出处： Efficacy and safety of Bacteroides fragilis BF839 for pediatric autism spectrum disorder: a randomized clinical trial<br>
                            https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1447059/full<br>
                            [2] ABC总分：BF839组改善幅度是安慰剂组的近4倍，表明它显著改善了自闭症儿童的整体行为问题。<br>
                            [2] ABC行为：BF839组这一指标上表现出显著改善，说明它对减少刻板行为有显著效果。<br>
                            [3] CARS评分：BF839组改善幅度是安慰剂组的2.6倍，表明它在改善自闭症核心症状方面效果显著。<br>
                            [4] BF839组胃肠道症状评分显著降低，说明它不仅能改善行为问题还能改善胃肠道症状。<br>
                        </small>

                    </div>
                    <div class="col-md-6">
                        <h4>肠菌移植(FMT)治疗孤独症的临床成果</h4>
                        <p>肠道菌群移植已经在干预孤独症方面取得较多临床证据，改善了多个症状，并正在临床上开展进行积极探索及应用</p>
                        <div class="table-responsive">
                        <table class="table table-bordered table-hover">
                            <thead class="table-custom">
                                <tr>
                                    <th scope="col">评估指标</th>
                                    <th scope="col">治疗前</th>
                                    <th scope="col">3个月改善</th>
                                    <th scope="col">6个月改善</th>
                                </tr>
                            </thead>
                            <tbody>
                                <tr>
                                    <th scope="row">ABC评分</th>
                                    <td>76.7 ± 24.6</td>
                                    <td>-13.0 ± 36.74</td>
                                    <td>-15.2 ± 36.6</td>
                                </tr>
                                <tr>
                                    <th scope="row">CARS评分</th>
                                    <td>35.2 ± 6.5</td>
                                    <td>-2.9 ± 8.9</td>
                                    <td>-5.1 ± 8.8</td>
                                </tr>
                                <tr>
                                    <th scope="row">BSFS评分</th>
                                    <td>3.0 ± 1.5</td>
                                    <td>+1.3 ± 2.3</td>
                                    <td>+2.0 ± 2.8</td>
                                </tr>
                                <tr>
                                    <th scope="row">GSRS评分</th>
                                    <td>11.9 ± 1.9</td>
                                    <td>-1.8 ± 2.8</td>
                                    <td>-2.0 ± 2.8</td>
                                </tr>
                            </tbody>
                        </table>
                        </div>
                        <small>
                            [1] 原文出处： 中华胃肠外科杂志 肠道菌群移植治疗合并便秘的孤独症谱系障碍328例临床疗效分析<br>
                            https://rs.yiigle.com/cmaid/1424291<br>
                            [2] ABC为孤独症行为量表，CARS为儿童孤独症评定量表，BSFS为Bristol粪便性状量表，GSRS为胃肠症状等级量表。<br>
                            [3] 原文数据为治疗后不同时点的量表测定值，此处中改为相比实验前的改善值，误差按 √(a² + b²)<br>
                            [4] 治疗期间及治疗后轻度不良反应比例为：腹胀6.4%、恶心4.3%、呕吐2.7%、腹痛4.6%，腹泻5.5%，发热4.0%、兴奋7.3%
                        </small>
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            <h2 class="text-center mb-4">二代菌+轻FMT+营养素：更令人期待的真实世界研究</h2>
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                    <h4>国家儿童医学中心知名专家亲任项目督导</h4>
                    <p>共计招募60+例5岁以下孩子入组，入组后将免费获得北京儿童医院儿童保健中心主任梁爱民教授及其研究团队的康复指导</p>
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                    <h4>二代菌及营养微生态医学原研团队全力支持</h4>
                    <p>入组可免费获得二代菌BF839+口服式轻FMT（混合益生菌）+高效吸收营养素</p>
                    <img src="https://totemlife.cn/apps/public/trial-highlight-2.png" class="img-fluid" alt="图腾生命医学">
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                <h2>马上登记，报名参加</h2>
                <p class="lead">本临床试验已开始接收报名，时间就是大脑，越早干预效果越好，请及早报名！</p>
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            <h2 class="text-center mb-4">参与步骤</h2>
            <p class="text-center mb-4">按照以下步骤报名参加临床试验，为孩子争取一个宝贵的干预机会！</p>
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                            <h5 class="card-title">步骤1、报名参加</h5>
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                            <h5 class="card-title">步骤2、面诊入组</h5>
                            <p class="card-text"> 前往<span style="color:red">北京面诊</span>后，凭入组通知书登记入组信息</p>
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                            <h5 class="card-title">步骤3、在组试验</h5>
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                            <a href="https://totemlife.cn/apps/space-journey/game" class="btn btn-outline-primary m-2" target="_blank">在组试验</a>
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